Front Matter -- Major Syndromes. Hereditary Breast and Ovarian Cancer Syndrome Including Isolated Ovarian Cancers -- Lynch Syndrome -- Neurofibromatosis -- Familial Adenomatous Polyposis -- Endocrine Neoplasia -- Hereditary Paraganglioma-pheochromocytoma -- Birt-Hogg-Dube Syndrome -- RASopathies -- Familial Malignant Melanoma -- Gorlin Syndrome -- Infracentesimal Syndromes. Li-Fraumeni Syndrome -- Ataxia-telangiectasia -- Hyperparathyroidism -- Hamartomatous Polyposis Syndromes -- Fanconi Syndrome -- Hereditary Diffuse Gastric Cancer -- Von Hippel-Lindau Disease -- Xeroderma Pigmentosum -- Hereditary Papillary Renal Carcinoma -- Retinoblastoma -- Carney Complex -- Hematological Malignancies -- Familial Pituitary Adenomas -- Bloom Syndrome -- Werner Syndrome -- Summary of the Book.