Front Matter -- Protein Folding and Quality Control in Drug Discovery. Epichaperomes as a Gateway to Understanding, Diagnosing, and Treating Disease Through Rebalancing Protein-Protein Interaction Networks / Chander S Digwal, Sahil Sharma, Anand R Santhaseela, Stephen D Ginsberg, Gabriela Chiosis -- Stability of Steroid Hormone Receptors / Zachary J Gale-Day, Jason E Gestwicki -- Pharmacological Chaperones / Suli-Anne Laurin, Sajjad Ahrari, Michel Bouvier -- Protein Degradation and Clearance as Drug Targeting Opportunities. Exploiting the Proteasome for Disease Treatment / Gwen R Buel, Xiuxiu Lu, Kylie J Walters -- Targeting the Ubiquitination Cascade for Drug Discovery / Qi Liu, Gabriel LaPlante, Wei Zhang -- Understanding, Targeting, and Hijacking Autophagy / Hongguang Xia, Xiaoyan Xu, Mengxin Zhou, Manke Zhang, Lingzhi Ye -- Deubiquitinating Enzymes / Xiaoxi Liu, Laura Doherty, Alejandra Felix, Sara Buhrlage -- Redirecting Protein Degradation Processes for Drug Development. History of IMiDs and Protein Degradation as a Pharmacological Modality / Junichi Yamamoto, Tomoko Asatsuma-Okumura, Takumi Ito, Yuki Yamaguchi, Hiroshi Handa -- PROTAC Degraders / Alessio Ciulli, Oliver Hsia -- Biochemical Principles of Targeted Protein Degradation / Roman V Agafonov, Richard W Deibler, William A Elam, Joe S Patel, Stewart L Fisher -- Pharmacology of PROTAC Degrader Molecules / Andy Pike, Sofia Guzzetti, Pablo M Gutierrez, James S Scott -- Emerging Technologies and Future Opportunities. Proximity-Inducing Bifunctional Molecules Beyond PROTACs / Sophia Lai, Ashley E Modell, Amit Choudhary -- Strategies for Tag-Based Protein Control / Behnam Nabet, Nathanael S Gray, Fleur M Ferguson -- Targeted Protein Degradation in Antiviral Drug Discovery / Mélissanne Wispelaere, Priscilla L Yang -- Beyond Inhibition / Milka Kostic, Lyn H Jones -- Index.