This book constitutes the refereed proceedings of the 28th International Conference on Enterprise Design, Operations, and Computing, EDOC 2024, held in Vienna, Austria, during September 10-13, 2024. The 18 full papers included in this book were carefully reviewed and selected from 70 submissions. They were organized in topical sections as follows: AI, ML and Agents; BPM and WFM; Business Models, Platforms and Strategic Management; Enterprise and IT Architecture; IT and Software Architecture; Modeling Methods, Data and Component; Process Mining and Monitoring; and Sustainability and Resilience.