This book covers autoimmune connective tissue diseases, an enigmatic area of dermatology that often pose a challenge to the treating dermatologists. The numerous presentations of systemic lupus erythematosus, the complications of systemic sclerosis, and the never-ending confusion regarding mixed connective tissue diseases are just the tip of an iceberg, making the subject look complex. On the contrary, once the concepts regarding pathogenesis and autoantibodies are cleared, treating these patients becomes less challenging. For a long time, we felt a gap in outlining a simple approach to these connective tissue diseases in the existing dermatology literature. This book has been written to explain the concepts in a less daunting manner and can be easily understood by both postgraduate residents and practicing consultants of dermatology. The chapters provide a systematic approach to the diagnosis and management of various connective tissue diseases with the help of tables/ algorithms and flowcharts. This book targets both postgraduate residents as well as practicing dermatologists. The complex subject of connective tissue diseases has been explained easily for better understanding and retention. It also highlights the holistic management of the patient.