This book constitutes the refereed proceedings of the 6th International Conference on Recent Trends in Image Processing and Pattern Recognition, RTIP2R 2023, held in Derby, UK, during December 2023, in collaboration with the Applied AI Research Lab at the University of South Dakota. The 62 full papers included in this book were carefully reviewed and selected from 216 submissions. The papers are organized in the following topical sections: Volume I: Artificial intelligence and applied machine learning; applied image processing and pattern recognition; and biometrics and applications. Volume II: Healthcare informatics; pattern recognition in blockchain, IOT, cyber plus network security, and cryptography.