The book provides an overview of various autoimmune disorders and how artificial intelligence (AI) and machine learning will be used for the diagnosis, prognosis, and treatment of these disorders. AI algorithms are used to create synthetic patient populations with the properties of actual patient cohorts, build personalized predictive models of drug combinations and unravel complex relationships between diet, microbiome, and genetic line-up to determine the comparative treatment response. The book highlights clinical applications and challenges of AI for the diagnosis and treatment/management of autoimmune disorders which includes Rheumatoid Arthritis (RA), Multiple Sclerosis (MS), Type I Diabetes, Psoriatic Arthritis (PsA), and other critical diseases.