This book aims to compile the latest scientific information on hand, foot, and mouth disease (HFMD), including its epidemiology, etiology, pathology, immune response and vaccine development. Interestingly, the authors shared their own research experience and offered distinctive insights into the pathogenesis of HFMD and vaccine development. The intended audience, including university researchers, graduate students, and vaccine engineers, is well defined. The book is positioned as a resource that not only presents current knowledge but also has the potential to inspire further research in understanding immune pathogenesis and advancing vaccine development for HFMD.