This volume constitutes the refereed proceedings of the Second International Conference on Computing, Communication and Learning, CoCoLe 2023, held in Warangal, India, in August 29-31, 2023. The 25 full papers presented were carefully reviewed and selected from 120 submissions. The CoCoLe conference focuses on Application of Supervised Learning in Computing; Application of Unsupervised Learning in Computing; and Computing in Communication Networks.