This volume contributes to the construction of a multi-voice mosaic on the theme of Nature and the relationship between Man (understood as designer) and Nature by emphasizing the innovative and sustainable proposals coming from the discipline of design, in its many facets and interdisciplinary contributions. Since it isn't discussed the creative and economic effort that designers, institutions and companies have been leading for years to improve human living conditions, preference will be given to scientific contributions (unpublished or not yet fully known case studies, projects of strategies, products, systems and services, theoretical contributions, communication) that are an expression of a new approach to Nature, seen as our ally and object of an ethics of care. The focus is the design both in its role as innovation driver and interpreter of social evolution, that must be considered within the human-nature relationship. The topics identify some of the most relevant fields of development in which "Design Driven Innovation" can be developed in the respect of perspective of a new relationship with nature.