The two volume set LNCS 14674 and 14675 constitutes the proceedings of the 10th International Work-Conference on the Interplay Between Natural and Artificial Computation, IWINAC 2024, which took place in Olhâo, Portugal, during June 4-7, 2024. The 99 full papers presented in these proceedings were carefully reviewed and selected from 193 submissions. They were organized in topical sections as follows: Part I: Machine learning in neuroscience; artificial intelligence in neurophysiology; neuromotor and cognitive disorders; intelligent systems for assessment, treatment, and assistance in early stages of Alzheimer's disease and other dementias; socio-cognitive, affective and physiological computing; affective computing and context awareness in ambientintelliigence; learning tools to lecture; Part II: Machine learning in computer vision and robotics; bio-inspired computing approaches; social and civil engineering through human AI translations; smart renewable energies: advancing AI algorithms in the renewable energy industry; bioinspired applications.