This book constitutes the refereed proceedings of the 20th IFIP WG 12.5 International Conference on Artificial Intelligence Applications and Innovations, AIAI 2024, held in Corfu, Greece, during June 27-30, 2024. The 100 full papers and 8 short papers included in this book were carefully reviewed and selected from 213 submissions. The diverse nature of papers presented demonstrates the vitality of AI algorithms and approaches. It certainly proves the very wide range of AI applications as well.