This book constitutes the proceedings of the 8th International Conference on Mathematical Software, ICMS 2024, held in Durham, UK, during July 22-25, 2024. The 37 full papers presented were carefully reviewed and selected from 46 submissions. The papers are organized in subject areas as follows: plenary lectures; number theory and related areas; novel formalisations of mathematics in lean; software for the applications of group theory to combinatorics; classical algebraic geometry & modern computer algebra: innovative software design and its applications; advancing computer algebra with massively parallel methods; computer algebra applications in the life sciences; machine learning within computer algebra systems; numerical software for special functions; mathematical research data; symbolic-numeric methods in algebraic geometry; Polyhedral geometry and combinatorics; general session.