This book presents contributions which discuss the impact of eXtended Reality (XR) and Artificial Intelligence (AI) technologies considered jointly in the fields of Cultural Heritage and Innovative Design. The rapid development of technologies, tools and devices requires a (controlled) expansion of the theoretical content and application areas, as well as careful monitoring of the disciplines that can be involved, starting with the AI-XR pair. XR, an acronym for extended reality, has emerged in recent years as a concept encompassing AR, VR (virtual reality), and MR (mixed reality), offering new ways of interacting with the real. In this sense, the fields of application open to the worlds of tangible and intangible cultural heritage, architectural, environmental, infrastructural and product design, and education, as a place for advanced training and as a tool for educational enhancement.