This book constitutes the refereed proceedings of the Third Southwest Data Science Conference, on Recent advances in next-generation data science, SDSC 2024, held in Waco, TX, USA, in March 22, 2024. The 15 full papers presented were carefully reviewed and selected from 59 submissions. These papers focus on AI security in next-generation data science and address a range of challenges, from protecting sensitive data to mitigating adversarial threats.