This book provides the most current advancements in the medical care of glioma patients, accompanied by clinical cases. Clinical implementations of the new multilayered integrated diagnosis of gliomas according to WHO CNS5 are also demonstrated here. New adjuvant therapies, such as chemotherapy/targeted therapy, immunotherapy, and physiotherapy, are discussed in the book. The book also covers the applications of genomics and epigenomics of gliomas in clinical practice. In essence, this book shows the management of gliomas with new treatment modalities, which can prolong the overall survival time of patients fighting glioma. The translation was done with the help of artificial intelligence. The present version has been revised technically and linguistically by the authors in collaboration with a professional translator.