The two-volume set CCIS 2236 and 2237 constitutes the refereed proceedings of the 7th International Conference on Applied Informatics, ICAI 2024, held in Vina del Mar, Chile, during October 24-26, 2024. The 39 full papers presented in these proceedings were carefully reviewed and selected from 123 submissions. The papers were organized in the following topical sections: Part I - Artificial Intelligence; Bioinformatics; Cloud Computing; Data Analysis; Decision Systems; and Game Development. Part II - Health Care Information Systems; Interdisciplinary Information Studies; Learning Management Systems; Natural Language Processing; Social and Behavioral Applications; Software and Systems Modeling; and Software Architectures.