This book serves as a clinical guide for the growing number of Advanced Practice Clinicians (APC) who care for stroke patients. It covers the entire spectrum of stroke care: acute, inpatient, and outpatient, as well as fundamental topics like neuroanatomy and radiology. Each chapter succinctly reviews crucial topics designed to guide APCs of any experience level with clinical decision-making. To further enrich the text, we incorporated guidelines, relevant trial data written in plain language, decision-making algorithms, clinical pearls, and case vignettes. Since this is a book for APCs, each chapter is written in a clear, clinically focused manner by an experienced APC with a collaborating physician. We hope this is a helpful resource not only for APCs in neurology but also for those practicing in other specialties, primary care, and students learning about stroke care.