This book constitutes the proceedings of the Second refereed proceedings of the Second International Conference on Data Science and Artificial Intelligence, DSAI 2024, held in Medan, Indonesia, during November 13-15, 2024. The 18 full papers, 2 short papers and 3 invited talks were included in this book were carefully reviewed and selected from 69 submissions. They are organized in the following topical sections: Keynote Presentations; Natural and Sign Language Processing; Applications of Data Science and Artificial Intelligence; Affective Computing and AI Games; Embedded AI and Applications; Data Science; AI and Healthcare.