Ubiquitination is a major protein post-translational modification, which is involved in many aspects of cellular procedure. The functions of ubiquitination in immune system and immune response have been intensively studied. This book aims to introduce the latest and crucial achievements, along with the fundamental principles of ubiquitination and immune responses. It covers the proteomic aspects of ubiquitination, the function of ubiquitin in innate and adoptive immunity, the development of immune cells, and the metabolism. The active researchers in this field are invited to contribute the chapters. This book is suitable for graduate students, researchers and readers who are interested in this field. It will provide readers with comprehensive insight into how ubiquitination functions in different aspects of immune system.