This book constitutes the refereed proceedings of the 22nd International Conference on Software Engineering and Formal Methods, SEFM 2024, held in Aveiro, Portugal, during November 6-8, 2024. The 23 full papers included in this book were carefully reviewed and selected from 68 submissions. The topics covered range from formal modelling, specification, and design in software development over safety-critical, fault-tolerant, and secure systems to real-time, hybrid, and cyber-physical systems and quantum computing.