This LNCS conference 4-volume set constitutes the proceedings of the 16th International Conference on Social Networks Analysis and Mining, ASONAM 2024, in Rende, Italy, during September 2-5, 2024. The 33 full papers together with 36 short papers included in this volume were carefully reviewed and selected from 167 submissions. The conference covers a wide spectrum of research contributions to the foundations and applications of social networks.