This book constitutes the refereed proceedings of the 5th EAI International Conference on Cognitive Computing and Cyber Physical Systems, IC4S 2024, held in Bhimavaram, India, during April 5-7, 2024. The 102 full papers presented were carefully reviewed and selected from 266 submissions. The proceedings focus on Cyber-physical systems, cognitive computing, Internet of Things, Smart grid, Security and trust management of CPS, Industrial IoT, Autonomous systems, Intelligent Transportation, Human-Machine Interaction, Distributed robotics, Sensor-based communication.