This volume LNCS 15277 constitutes the refereed proceedings of the 18th Ibero-American Conference on AI, IBERAMIA 2024, held in Montevideo, Uruguay, during November 13-15, 2024. The 36 full papers presented together with 14 short papers were carefully reviewed and selected from 96 submissions. The conference focuses on AI engineering & applications; bio-inspired & soft computing; computer vision & robotics; knowledge representation & reasoning; machine learning; multi agent systems; natural language processing; and social AI.