This book takes a comprehensive approach to exploring the connection between Membrane proteins' (MPs) structures and functions, employing the principles of chemical kinetics. It systematically presents the physical properties and biological significance of electrostatic membrane potential, while also analyzing the structure-function relationships within various MP families based on the principle of membrane-potential driving force among other novel concepts. To enhance understanding, the functional mechanisms of MPs are explained in accessible language and illustrated with simplified models. Whether utilized as a supplementary textbook for undergraduate and postgraduate students specializing in molecular biology and physics, or as a reference guide for researchers in related fields, this book offers valuable insights into the intricate world of structural biology.