This book provides research-based advancements into the effects of changing environmental conditions on the diverse plant-symbiont community. It summarizes the mechanisms employed by the microorganisms to improve plant tolerance towards the extreme climatic conditions. These mechanisms include metabolite exchange and metabolic cross-talk in the microbiome-root-shoot-environment nexus. This book also describes the recently discovered phenomenon, systematically-induced root exudation of metabolites, which explains how the rhizosphere microbiome governs the plant metabolism by inducing a systemic shift in root exudate metabolites. This book is then concluded by highlighting the role of advanced meta-omics tools and systemic metabolic engineering approaches in generating climate-resilient crops and microbes to tackle the cumulative degradation of soil health in agro-ecosystems. This book is a reference for students, researchers and policymakers working in the field of microbiology, soil science, plant science, climate change and sustainable agriculture.