This book constitutes revised selected papers of the 12th International Symposium on From Data Models and Back, DataMod 2024, held in Aveiro, Portugal, during November 4-5, 2024. The 9 full papers included in this book were carefully reviewed and selected from 15 submissions. These papers present research results in the areas of knowledge management, data mining and machine learning, as well as application experiences, tools and promising preliminary ideas. .