This book presents the combined proceedings of the 16th International Conference on Computer Science and its Applications (CSA 2024) in Pattaya, Thailand, December 18-20, 2024. The aim of this meeting was to promote discussion and interaction among academics, researchers and professionals in the field of ubiquitous computing technologies and computer science and its applications. These proceedings reflect the state of the art in the development of computational methods, involving theory, algorithms, numerical simulation, error and uncertainty analysis and novel applications of new processing techniques in engineering, science and other disciplines related to ubiquitous computing.