This book constitutes the refereed proceedings of the 10th International Symposium on End-User Development, IS-EUD 2025, held in Munich, Germany, during June 16-18, 2025. The 13 full papers and 8 short papers included in this book were carefully reviewed and selected from 25 submissions. These papers have been organized under the following topical sections: Automation, Sustainability, and Smart Environments; Democratizing AI and Programming; AI for End-User Empowerment: Personalization andWellbeing; and EUD Principles, Methodologies, and Participatory Cultures.