This two-volume set LNCS 15762-15763 constitutes the proceedings of the 22nd International Conference on the Integration of Constraint Programming, Artificial Intelligence, and Operations Research, CPAIOR 2025, held in Melbourne, VIC, Australia, November 10-13, 2025. The 30 full papers and the 2 short papers presented in the proceedings were carefully reviewed and selected from a total of 68 submissions. The conference featured a masterclass and several joint invited talks that covered topics of interest at the intersection of constraint programming, artificial Intelligence, operations research, planning and scheduling, and knowledge representation.