This two-volume set constitutes the refereed proceedings of the 21st IFIP WG 5.1 International Conference on Product Lifecycle Management, PLM 2024, held in Bangkok, Thailand, during July 7-10, 2024. The 64 full papers presented in this book were carefully reviewed and selected from 105 submissions. PLM 2024 aims to integrate business approaches to the collaborative creation, management and dissemination of product and process data throughout the extended enterprises that create, manufacture and operate engineered products and systems.