This book presents the proceedings of the 4th International Conference on Advanced Computing and Informatics (ICACIn'24). The conference, held on December 16-17, 2024, at STEAMhouse, Birmingham City University (UK), with a parallel session at Hassan II University (Morocco), attracted submissions by researchers in 20 countries. Out of 91 submissions, 46 high-quality papers were selected, presenting the latest advancements and cutting-edge developments in computing and informatics. The book covers a wide range of advanced computing topics, including data science, big data analytics, the Internet of Things (IoT), smart computing, artificial intelligence, machine learning, cybersecurity, intelligent communication systems, health informatics, and information systems. Designed for researchers, practitioners, and graduate students, this book serves as a valuable resource for exploring advanced intelligent computing techniques and their real-world applications.