This book constitutes the refereed proceedings of the 12th International Conference on Learning Technology for Education Challenges, LTEC 2025, held in Kota Kinabalu, Malaysia, during August 2025. The 26 full papers included in this book were carefully reviewed and selected from 52 submissions. They were organized in topical sections as follows: artificial intelligence in learning; learning practices and methodologies; learning technologies and tools; gamification and serious games; evaluation and learning analysis; and STEM education.