This new edition is an easy-to-read guide outlining specific differences in communication, clinical therapies, medications, protocols, and other critical precision medicine approaches to the care of African Americans. African Americans still face significant health disparities in the United States across numerous health measures. Despite their uniquely poor health outcomes, no other book has taken a laser focus on this community and shed light on best practices based on confirmed and replicated research outcomes. From cardiovascular disease to cancer, the physiology, pharmacology, prevention, and other interventions are, in many cases, uniquely different for African Americans. As such, the optimal approach to achieving the best outcomes is different. This updated edition expands on the success of the first with a distinct precision medicine approach. Data is updated throughout to improve and refine the perspectives given. New sections have been added covering bias, pain, emotional and cultural intelligence, and sickle cell disease. Updated, expanded, and including more specialists in their field, this second edition advances approaches and practices that continue to benefit the clinical care of African Americans.