This book contains extended versions of the works and new research results presented at the 15th International Conference on Artificial Intelligence-empowered Software Engineering (AIESE2024, formerly Joint Conference on Knowledge-based Software Engineering, JCKBSE), University of Piraeus, August 27-30, 2024, Greece. AIESE (formerly JCKBSE) is a well-established international biennial conference that focuses on the applications of Artificial Intelligence on Software Engineering. Its 15th edition was organized by the Department of Informatics of the University of Piraeus, Greece. This book is a valuable resource for experts and researchers in the field of (artificial intelligence-empowered and knowledge-based) software engineering. It is also valuable to general readers in the fields of artificial and computational intelligence and, more generally, computer science, who wish to learn more about this exciting research field of software engineering and its applications. An extensive list of bibliographic references at the end of each chapter helps readers to probe deeper into the application areas of interest to them.