This updated third edition of the very successful Handbook of Physiology - Microcirculation highlights the central role of microcirculation in all major cardiovascular functions. As the primary site of oxygen and nutrient exchange in any tissue, the microcirculation is also where other important phenomena are regulated. These include, blood pressure, blood flow and inflammatory responses. As alterations in microvascular function are major contributors to a host of diseases, an understanding of microcirculatory function is crucial for physiologists, health care professionals, and bioengineers. Readers will gain insights into microvascular exchange functions, angiogenesis, the role of the endothelial glycocalyx in human disease, cerebral microcirculation and coronary microvascular resistance. The volume also addresses novel findings related to tumor microcirculation abnormalities, microvascular dysfunction related to COVID-19, and systemic inflammation and the impact of cannabinoids on microvascular health. Advances in computational models for the investigation of microvascular remodelling and the imaging of microvascular morphology and hemodynamics are also discussed. This volume is indispensable for those seeking to understand the complexities of microvascular function and its implications for health and disease. Whether you are a researcher, clinician, or student, this book provides the latest research and expert analysis in the field of microcirculation.