This book, in its 2nd edition, is a collection of cases with challenging diagnosis, in which nuclear medicine examinations have been particularly helpful for the clinicians to perform the final diagnosis or to follow-up the patient. The cases selected are primarily in patients with neurodegenerative disorders, epilepsy and brain tumors. Authors have been selected from internationally recognized experts in the field of Neuroimaging in neurology. All authors have large experience as clinicians and as teachers within the Nuclear Medicine community. The volume includes cases related to emerging topics such as theranostics for brain tumors and new emerging scenarios for brain PET imaging in the era of Alzheimer's disease modifying drugs. The book is intended for nuclear medicine specialists as well as clinicians to provide guidance in the interpretation of neurology cases in the clinical settings, particularly with regards to correct approach to the interpretation of diagnostic imaging procedures.