This book constitutes the thoroughly refereed post-conference proceedings of the 10th International Symposium on Trustworthy Global Computing, TGC 2015, held in Madrid, Spain, in August/September 2015. The 10 revised full papers presented were carefully reviewed and selected from 19 submissions. The Symposium on Trustworthy Global Computing focuses on frameworks, tools, algorithms, and protocols for open-ended, large-scale systems and applications, and on rigorous reasoning about their behavior and properties.