This book constitutes the proceedings of the 13th International Conference on Information Security and Practice and Experience, ISPEC 2017, held in Melbourne, Australia, in December 2017. The 34 full and 14 short papers presented together with 9 papers from the SocialSec Track in this volume were carefully reviewed and selected from 105 submissions. The papers cover topics such as blockchain, asymmetric encryption, symmetric encryption, lattice-based cryptography, searchable encryption, signature, authentication, cloud security, network security, cyber-physical security, social network and QR code security, software security and trusted computing, and SocialSec track.