This book constitutes the proceedings of the 5th International Conference on Context-Aware Systems and Applications, ICCASA 2016, held in Thu Dau Mot, Vietnam, in November 2016. The 22 revised full papers presented were carefully selected from 35 submissions and cover a wide spectrum in the area of Context-Aware-Systems (CAS). CAS is characterized by its self- facets such as self-organization, self-configuration, self-healing, self-optimization, self-protection, where context awareness used to dynamically control computing and networking functions. The overall goal of CAS is to realize nature-inspired autonomic systems that can manage themselves without direct human interventions.