This book constitutes the proceedings of the 18th International GI/ITG Conference on Measurement, Modelling and Evaluation of Computing Systems and Dependability and Fault Tolerance, MMB & DFT 2016, held in Münster, Germany, in April 2016. The 12 full papers and 3 short papers included in this volume were carefully reviewed and selected from 23 submissions. The papers deal with the fields of performance evaluation, dependability, and fault-tolerance of computer and communication systems. A relatively new topic of smart grids is also covered.