This book constitutes the refereed proceedings of the 18th International Conference on Verification, Model Checking, and Abstract Interpretation, VMCAI 2017, held in Paris, France, in January 2017. The 27 full papers together with 3 invited keynotes presented were carefully reviewed and selected from 60 submissions. VMCAI provides topics including: program verification, model checking, abstract interpretation and abstract domains, program synthesis, static analysis, type systems, deductive methods, program certification, debugging techniques, program transformation, optimization, hybrid and cyber-physical systems. .