This book constitutes the thoroughly refereed post-conference proceedings of the Second International Workshop on Computer Assisted and Robotic Endoscopy, CARE 2015, held in conjunction with MICCAI 2015, in Munich, Germany, in October 2015. The 15 revised full papers were carefully selected out of 20 initial submissions and focus on recent technical advances associated with computer vision; graphics; robotics and medical imaging; external tracking systems; medical device control systems; information processing techniques; endoscopy; planning and simulation.