This book constitutes the conference proceedings of the 16th International Symposium on Intelligent Data Analysis, which was held in October 2017 in London, UK. The 28 full papers presented in this book were carefully reviewed and selected from 66 submissions. The traditional focus of the IDA symposium series is on end-to-end intelligent support for data analysis. IDA solicits papers on all aspects of intelligent data analysis, including papers on intelligent support for modelling and analyzing data from complex, dynamical systems.