This book constitutes the thoroughly refereed post-conference proceedings of the International Conference for Smart Health, ICSH 2016, held in Haikou, Hainan, China, in December 2016. The 23 full papers presented were carefully reviewed and selected from 52 submissions.They are organized around the following topics: big data and smart health; health data analysis and management; healthcare intelligent systems and clinical practice; medical monitoring and information extraction; clinical and medical data mining.