This book is about the transformation of the biomedical information to smart healthcare, the chapters are designed to discuss the health associated factors such as genetics, lifestyle, nutrition and environmental factors. The interactions of these factors and the informatics for the analyses of their effects on health are also covered. The era of aging is approaching and the P4 (predictive, preventive, personalized and participatory) medicine paradigm is becoming practical and reality. According to the Kondratiev's long wave theory, IT (information technology) and health will be the next technological revolution for the new economic cycle. This book is written for biomedical informatics scientists, clinicians, health practitioners and researchers, etc.