This book constitutes the refereed conference proceedings of the 15th International Conference on Intelligent Data Analysis, which was held in October 2016 in Stockholm, Sweden. The 36 revised full papers presented were carefully reviewed and selected from 75 submissions. The traditional focus of the IDA symposium series is on end-to-end intelligent support for data analysis. The symposium aims to provide a forum for inspiring research contributions that might be considered preliminary in other leading conferences and journals, but that have a potentially dramatic impact. .