This book constitutes the proceedings of the 12th International Conference on Advanced Data Mining and Applications, ADMA 2016, held in Gold Coast, Australia, in December 2016. The 70 papers presented in this volume were carefully reviewed and selected from 105 submissions. The selected papers covered a wide variety of important topics in the area of data mining, including parallel and distributed data mining algorithms, mining on data streams, graph mining, spatial data mining, multimedia data mining, Web mining, the Internet of Things, health informatics, and biomedical data mining.