The two-volume set, LNCS 10492 and LNCS 10493 constitutes the refereed proceedings of the 22nd European Symposium on Research in Computer Security, ESORICS 2017, held in Oslo, Norway, in September 2017. The 54 revised full papers presented were carefully reviewed and selected from 338 submissions. The papers address issues such as data protection; security protocols; systems; web and network security; privacy; threat modeling and detection; information flow; and security in emerging applications such as cryptocurrencies, the Internet of Things and automotive.