This book constitutes the refereed proceedings of the 15th International Conference of the Italian Association for Artificial Intelligence, AI*IA 2016, held in Genova, Italy, in November/December 2016. The 39 full papers presented were carefully reviewed and selected from 53 submissions. The papers are organized in topical sections on optimization and evolutionary algorithms; classification, pattern recognition, and computer vision; multi-agent systems; machine learning; semantic web and description logics; natural language processing; planning and scheduling; and formal verification.