This book constitutes the refereed proceedings of the 10th International Andrei Ershov Informatics Conference, PSI 2015, held in Kazan and Innopolis, Russia, in August 2015. The 2 invited and 23 full papers presented in this volume were carefully reviewed and selected from 56 submissions. The papers cover various topics related to the foundations of program and system development and analysis, programming methodology and software engineering and information technologies.